1 Capsazepine has recently been described as a competitive capsaicin antagonist. We have
used this compound to test the hypotheses that the in vitro and in vivo effects of capsaicin
are due to interactions with a specific receptor. 2 In an in vitro preparation of the neonatal rat
spinal cord with functionally connected tail, the activation of nociceptive afferent fibres by the
application of capsaicin, bradykinin or noxious heat (48° C) to the tail could be measured by
recording a depolarizing response from a spinal ventral root. Application of capsaicin or …

Selective antagonism of capsaicin by capsazepine : evidence for a spinal receptor site in
capsaicin-induced antinociception | CiNii Research … Selective antagonism of capsaicin by
capsazepine : evidence for a spinal receptor site in capsaicin-induced antinociception …